Protein Family Models

This entry represents flotillin-like protein FloA from bacteria. Bacterial flotillin-like proteins are found in membrane microdomains that may be equivalent to eukaryotic membrane rafts [1]. Similarly to eukaryotic flotillin proteins, flotillins in bacteria play an essential role in organising and maintaining the correct architecture of the functional membrane microdomains [2,3]. Bacillus subtilis has two flotillin paralogs, FloT and FloA. The absence of one of the flotillins has only minor effects, but the absence of both proteins has very severe effects: loss of proper cell shape, a defect in cell division [3]. [1]. 20713508. Functional microdomains in bacterial membranes. Lopez D, Kolter R;. Genes Dev. 2010;24:1893-1902. [2]. 25652542. Exploring the existence of lipid rafts in bacteria. Bramkamp M, Lopez D;. Microbiol Mol Biol Rev. 2015;79:81-100. [3]. 27362352. Super Resolution Fluorescence Microscopy and Tracking of Bacterial Flotillin (Reggie) Paralogs Provide Evidence for Defined-Sized Protein Microdomains within the Bacterial Membrane but Absence of Clusters Containing Detergent-Resistant Proteins. Dempwolff F, Schmidt FK, Hervas AB, Stroh A, Rosch TC, Riese CN, Dersch S, Heimerl T, Lucena D, Hulsbusch N, Stuermer CA, Takeshita N, Fischer R, Eckhardt B, Graumann PL;. PLoS Genet. 2016;12:e1006116. (from Pfam)

Date:

2024-10-16

flotillin-like FloA family protein similar to Bacillus subtilis YqfA that is present exclusively in functional membrane microdomains and is homologous to eukaryotic lipid raft-specific flotillin proteins

Date:

2020-04-21

Gene:

floA

Date:

2020-10-26