Protein Family Models

Clusters of short DNA repeats with non-homologous spacers, which are found at regular intervals in the genomes of phylogenetically distinct prokaryotic species, comprise a family with recognisable features. This family is known as CRISPR (short for Clustered Regularly Interspaced Short Palindromic Repeats). A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-associated) proteins [1]. This entry represents Csm2 Type III-A, a family of Cas proteins also known as TM1810/Csm2 [2]. [1]. 17442114. Evolutionary conservation of sequence and secondary structures in CRISPR repeats. Kunin V, Sorek R, Hugenholtz P;. Genome Biol. 2007;8:R61. [2]. 21552286. Evolution and classification of the CRISPR-Cas systems. Makarova KS, Haft DH, Barrangou R, Brouns SJ, Charpentier E, Horvath P, Moineau S, Mojica FJ, Wolf YI, Yakunin AF, van der Oost J, Koonin EV;. Nat Rev Microbiol. 2011;9:467-477. (from Pfam)

Gene:

csm2

Date:

2024-10-16

These proteins are found adjacent to a characteristic short, palidromic repeat cluster termed CRISPR, a probable mobile DNA element. This HMM represents the C-terminal domain of a minor family of CRISPR-associated protein from the Mtube subtype of CRISPR/Cas locus. The family is designated Csm2, for CRISPR/Cas Subtype Mtube Protein 2.

Gene:

csm2

Date:

2024-08-07