Protein Family Models

Flotillin is a family of lipid-membrane-associated proteins found in bacteria, archaea and eukaryotes. The family is found in association with Pfam:PF01145, another integral membrane-associated domain. Flotillins in vertebrates are associated with sphingolipids and cholesterol-enriched membrane microdomains known as lipid-rafts. These rafts along with other membrane components are important in cell-signalling. Flotillins in other organisms have roles in viral pathogenesis, endocytosis, and membrane shaping. [1]. 20018678. Plant flotillins are required for infection by nitrogen-fixing bacteria. Haney CH, Long SR;. Proc Natl Acad Sci U S A. 2010;107:478-483. [2]. 22194304. The roles of flotillin microdomains--endocytosis and beyond. Otto GP, Nichols BJ;. J Cell Sci. 2011;124:3933-3940. [3]. 22215737. Flotillin-1 (Reggie-2) contributes to Chlamydia pneumoniae growth and is associated with bacterial inclusion. Korhonen JT, Puolakkainen M, Haivala R, Penttila T, Haveri A, Markkula E, Lahesmaa R;. Infect Immun. 2012;80:1072-1078. [4]. 22882210. The biofilm formation defect of a Bacillus subtilis flotillin-defective mutant involves the protease FtsH. Yepes A, Schneider J, Mielich B, Koch G, Garcia-Betancur JC, Ramamurthi KS, Vlamakis H, Lopez D;. Mol Microbiol. 2012;86:457-471. (from Pfam)

Date:

2024-10-16

This family has been called SPFH [1], Band 7 or PHB domain. Recent phylogenetic analysis has shown this domain to be a slipin or Stomatin-like integral membrane domain conserved from protozoa to mammals. [1]. 10542406. The SPFH domain: implicated in regulating targeted protein turnover in stomatins and other membrane-associated proteins. Tavernarakis N, Driscoll M, Kyrpides NC;. Trends Biochem Sci 1999;24:425-427. [2]. 18267007. Slipins: ancient origin, duplication and diversification of the stomatin protein family. Green JB, Young JP;. BMC Evol Biol. 2008;8:44. (from Pfam)

Date:

2024-10-16

flotillin family protein may act as a scaffolding protein within caveolar membranes, functionally participating in the formation of caveolae or caveolae-like vesicles

Date:

2017-10-05