Protein Family Models

This family appears to have methyltransferase activity. (from Pfam)

Date:

2024-08-14

This family appears to be a methyltransferase domain. (from Pfam)

Date:

2024-08-14

This family appears to be a methyltransferase domain. (from Pfam)

Date:

2024-08-14

Members of this family are SAM dependent methyltransferases. (from Pfam)

Date:

2024-08-14

Members of this family are SAM dependent methyltransferases. (from Pfam)

Date:

2024-08-14

This family consists of several bacterial and one archaeal methionine biosynthesis MetW proteins. Biosynthesis of methionine from homoserine in Pseudomonas putida takes place in three steps. The first step is the acylation of homoserine to yield an acyl-L-homoserine. This reaction is catalysed by the products of the metXW genes and is equivalent to the first step in enterobacteria, gram-positive bacteria and fungi, except that in these microorganisms the reaction is catalysed by a single polypeptide (the product of the metA gene in Escherichia coli and the met5 gene product in Neurospora crassa). In Pseudomonas putida, as in gram-positive bacteria and certain fungi, the second and third steps are a direct sulfhydrylation that converts the O-acyl-L-homoserine into homocysteine and further methylation to yield methionine. The latter reaction can be mediated by either of the two methionine synthetases present in the cells [1]. [1]. 11479715. The methionine biosynthetic pathway from homoserine in Pseudomonas putida involves the metW, metX, metZ, metH and metE gene products. Alaminos M, Ramos JL;. Arch Microbiol 2001;176:151-154. (from Pfam)

Date:

2024-10-16

This family consists of nodulation S (NodS) proteins. The products of the rhizobial nodulation genes are involved in the biosynthesis of lipochitin oligosaccharides (LCOs), which are host-specific signal molecules required for nodule formation. NodS is an S-adenosyl-L-methionine (SAM)-dependent methyltransferase involved in N methylation of LCOs. NodS uses N-deacetylated chitooligosaccharides, the products of the NodBC proteins, as its methyl acceptors [1]. [1]. 11344149. Rhizobial NodL O-acetyl transferase and NodS N-methyl transferase functionally interfere in production of modified Nod factors. Lopez-Lara IM, Kafetzopoulos D, Spaink HP, Thomas-Oates JE;. J Bacteriol 2001;183:3408-3416. (from Pfam)

Date:

2024-10-16

This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences. [1]. 8226664. Cotranscription of two genes necessary for ribosomal protein L11 methylation (prmA) and pantothenate transport (panF) in Escherichia coli K-12. Vanet A, Plumbridge JA, Alix JH;. J Bacteriol 1993;175:7178-7188. (from Pfam)

Date:

2024-10-16

This domain is found in ribosomal RNA small subunit methyltransferase C (eg Swiss:P44453) as well as other methyltransferases (eg Swiss:Q53742). (from Pfam)

Date:

2024-08-14

This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyse the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. [1]. 8917504. A common mechanism for the biosynthesis of methoxy and cyclopropyl mycolic acids in Mycobacterium tuberculosis. Yuan Y, Barry CE 3rd;. Proc Natl Acad Sci U S A 1996;93:12828-12833. [2]. 7592990. The biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Identification and functional analysis of CMAS-2. George KM, Yuan Y, Sherman DR, Barry CE 3d;. J Biol Chem 1995;270:27292-27298. [3]. 10882107. A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis. Glickman MS, Cox JS, Jacobs WR Jr;. Mol Cell. 2000;5:717-727. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14