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Links from Protein

Items: 6

1.

quinolinate synthase NadA

Quinolinate synthetase catalyses the second step of the de novo biosynthetic pathway of pyridine nucleotide formation. In particular, quinolinate synthetase is involved in the condensation of dihydroxyacetone phosphate and iminoaspartate to form quinolinic acid [2]. This synthesis requires two enzymes, a FAD-containing "B protein" and an "A protein". [1]. 2841129. Molecular biology of pyridine nucleotide biosynthesis in Escherichia coli. Cloning and characterization of quinolinate synthesis genes nadA and nadB. Flachmann R, Kunz N, Seifert J, Gutlich M, Wientjes FJ, Laufer A , Gassen HG;. Eur J Biochem 1988;175:221-228. [2]. 10648170. Cloning, overexpression, and purification of Escherichia coli quinolinate synthetase. Ceciliani F, Caramori T, Ronchi S, Tedeschi G, Mortarino M, Galizzi A;. Protein Expr Purif 2000;18:64-70. (from Pfam)

Gene:
nadA
GO Terms:
Molecular Function:
quinolinate synthetase A activity (GO:0008987)
Biological Process:
NAD biosynthetic process (GO:0009435)
Molecular Function:
4 iron, 4 sulfur cluster binding (GO:0051539)
Date:
2024-10-16
Family Accession:
NF014498.5
Method:
HMM
2.
new record, indexing in progress
Family Accession:
3.
new record, indexing in progress
Family Accession:
4.

quinolinate synthase

quinolinate synthase NadA catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate, the second step in the de novo biosynthesis of NAD(+) from aspartate

Date:
2022-08-18
Family Accession:
10013208
Method:
Sparcle
5.

quinolinate synthase

This protein, termed NadA, plays a role in the synthesis of pyridine, a precursor to NAD. The quinolinate synthetase complex consists of A protein (this protein) and B protein. B protein converts L-aspartate to iminoaspartate, an unstable reaction product which in the absence of A protein is spontaneously hydrolyzed to form oxaloacetate. The A protein, NadA, converts iminoaspartate to quinolate.

Gene:
nadA
GO Terms:
Molecular Function:
quinolinate synthetase A activity (GO:0008987)
Biological Process:
pyridine nucleotide biosynthetic process (GO:0019363)
Date:
2021-05-12
Family Accession:
TIGR00550.1
Method:
HMM
6.

quinolinate synthase NadA

Gene:
nadA
GO Terms:
Molecular Function:
quinolinate synthetase A activity (GO:0008987)
Biological Process:
NAD biosynthetic process (GO:0009435)
Date:
2021-10-28
Family Accession:
NF006885.0
Method:
HMM
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