Protein Family Models

Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway [1]. In these bifunctional proteins (e.g. Swiss:O67982) CMD represents the C-terminal domain, Pfam:PF00561 represents the N-terminal domain. [1]. 9495744. Characterization of a protocatechuate catabolic gene cluster from Rhodococcus opacus 1CP: evidence for a merged enzyme with 4-carboxymuconolactone-decarboxylating and 3-oxoadipate enol-lactone-hydrolyzing activity. Eulberg D, Lakner S, Golovleva LA, Schlomann M;. J Bacteriol 1998;180:1072-1081. [2]. 16597838. Crystal structure of the conserved protein TTHA0727 from Thermus thermophilus HB8 at 1.9 A resolution: A CMD family member distinct from carboxymuconolactone decarboxylase (CMD) and AhpD. Ito K, Arai R, Fusatomi E, Kamo-Uchikubo T, Kawaguchi S, Akasaka R, Terada T, Kuramitsu S, Shirouzu M, Yokoyama S;. Protein Sci. 2006;15:1187-1192. (from Pfam)

Date:

2024-10-16

carboxymuconolactone decarboxylase family protein similar to Escherichia coli protein YnjA and Bacillus subtilis protein YdfG

Date:

2024-04-17