Protein Family Models

This entry represents the N-terminal helical bundle domain from proteins in the TACO1/YebC family which are thought to act as transcriptional regulators. In mammals, The TACO1 protein activates the translation of mitochondrially-encoded COX1 [2,4]. In bacteria, it negatively regulates the quorum-sensing response regulator by binding to its promoter region [3]. [1]. 12060744. Crystal structure of conserved hypothetical protein Aq1575 from Aquifex aeolicus. Shin DH, Yokota H, Kim R, Kim SH;. Proc Natl Acad Sci U S A. 2002;99:7980-7985. [2]. 19503089. Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome. Weraarpachai W, Antonicka H, Sasarman F, Seeger J, Schrank B, Kolesar JE, Lochmuller H, Chevrette M, Kaufman BA, Horvath R, Shoubridge EA;. Nat Genet. 2009;41:833-837. [3]. 18641136. The YebC family protein PA0964 negatively regulates the Pseudomonas aeruginosa quinolone signal system and pyocyanin production. Liang H, Li L, Dong Z, Surette MG, Duan K;. J Bacteriol. 2008;190:6217-6227. [4]. 27319982. Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Richman TR, Spahr H, Ermer JA, Davies SM, Viola HM, Bates KA, Papadimitriou J, Hool LC, Rodger J, Larsson NG, Rackham O, Filipovska A;. Nat Commun. 2016;7:11884. (from Pfam)

Date:

2024-10-16

This is a family of transcriptional regulators. In mammals, it activates the transcription of mitochondrially-encoded COX1 [2]. In bacteria, it negatively regulates the quorum-sensing response regulator by binding to its promoter region [3]. This entry represents the second and third domains in this protein, with one domain nested within the other. [1]. 12060744. Crystal structure of conserved hypothetical protein Aq1575 from Aquifex aeolicus. Shin DH, Yokota H, Kim R, Kim SH;. Proc Natl Acad Sci U S A. 2002;99:7980-7985. [2]. 19503089. Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome. Weraarpachai W, Antonicka H, Sasarman F, Seeger J, Schrank B, Kolesar JE, Lochmuller H, Chevrette M, Kaufman BA, Horvath R, Shoubridge EA;. Nat Genet. 2009;41:833-837. [3]. 18641136. The YebC family protein PA0964 negatively regulates the Pseudomonas aeruginosa quinolone signal system and pyocyanin production. Liang H, Li L, Dong Z, Surette MG, Duan K;. J Bacteriol. 2008;190:6217-6227. (from Pfam)

Date:

2024-10-16

YebC/PmpR family DNA-binding transcriptional regulator may play important roles in gene regulation and/or pathogenesis

Date:

2023-03-22

Date:

2020-10-26