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efflux RND transporter permease subunit
Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer [1]. [1]. 12374972. Crystal structure of bacterial multidrug efflux transporter AcrB. Murakami S, Nakashima R, Yamashita E, Yamaguchi A;. Nature 2002;419:587-593. (from Pfam)
efflux RND transporter permease subunit is an efflux protein similar to Escherichia coli multidrug export protein AcrF (acriflavine resistance protein F), part of the tripartite efflux system AcrEF-TolC that is involved in the efflux of indole and organic solvents
Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of Pfam HMM PF00873.
multidrug efflux RND transporter permease subunit
Multidrug efflux RND transporter permease subunits that belong to this family include OqxB, AcrB, AcrD, AcrF, MdtF, AdeE, AdeJ, MexB, etc.
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