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DNA polymerase thumb domain-containing protein
This is the thumb domain found in DNA polymerase iota and related proteins. This domain makes contacts with the minor groove of DNA. Paper describing PDB structure 1t3n. [1]. 15254543. Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing. Nair DT, Johnson RE, Prakash S, Prakash L, Aggarwal AK;. Nature. 2004;430:377-380. Paper describing PDB structure 2alz. [2]. 16216587. Human DNA polymerase iota incorporates dCTP opposite template G via a G.C + Hoogsteen base pair. Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK;. Structure. 2005;13:1569-1577. Paper describing PDB structure 2aq4. [3]. 16195463. Rev1 employs a novel mechanism of DNA synthesis using a protein template. Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK;. Science. 2005;309:2219-2222. Paper describing PDB structure 2dpi. [4]. 16819516. Hoogsteen base pair formation promotes synthesis opposite the 1,N6-ethenodeoxyadenosine lesion by human DNA polymerase iota. Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK;. Nat Struct Mol Biol. 2006;13:619-625. Paper describing PDB structure 3gqc. [5]. 19464298. Structure of the human Rev1-DNA-dNTP ternary complex. Swan MK, Johnson RE, Prakash L, Prakash S, Aggarwal AK;. J Mol Biol. 2009;390:699-709. (from Pfam)
impB/mucB/samB family C-terminal domain
These proteins are involved in UV protection (Swiss). (from Pfam)
IMS family HHH motif
These proteins are involved in UV protection, eg (Swiss:P07375). (from Pfam)
impB/mucB/samB family
DNA polymerase IV
DNA polymerase IV facilitates translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions
Involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
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