Protein Family Models

This is the VTT (VMP1, TMEM41, and TVP38) domain found in sequences from all cellular organisms, including Golgi apparatus membrane protein TVP38 from Saccharomyces cerevisiae, which is involved in vesicular trafficking and spindle migration [1,2]. This domain was previously called SNARE-associated domain but was renamed as there is no evidence that it associates with SNARE proteins [3]. [1]. 16107716. Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments. Inadome H, Noda Y, Adachi H, Yoda K;. Mol Cell Biol. 2005;25:7696-7710. [2]. 17178117. Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-containing Golgi/endosome compartments of Saccharomyces cerevisiae. Inadome H, Noda Y, Kamimura Y, Adachi H, Yoda K;. Exp Cell Res. 2007;313:688-697. [3]. 30093494. Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation. Morita K, Hama Y, Izume T, Tamura N, Ueno T, Yamashita Y, Sakamaki Y, Mimura K, Morishita H, Shihoya W, Nureki O, Mano H, Mizushima N;. J Cell Biol. 2018;217:3817-3828. (from Pfam)

Date:

2024-10-16

Rhodanese has an internal duplication. This Pfam represents a single copy of this duplicated domain. The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases. Crystal structure. [1]. 8702871. Active site structural features for chemically modified forms of rhodanese. Gliubich F, Gazerro M, Zanotti G, Delbono S, Bombieri G, Berni R;. J Biol Chem 1996;271:21054-21061. (from Pfam)

Date:

2024-10-16

DedA and RHOD domain-containing protein

Date:

2017-03-02