Protein Family Models

An uncharacterized alpha helical domain containing a highly conserved ER motif and typically found as a tandem duplication. Contextual analysis suggests that it functions in a distinct peptide synthesis/modification system comprising of a transglutaminase, a peptidase of the NTN-hydrolase superfamily, an active and inactive circularly permuted ATP-grasp domains and a transglutaminase fused N-terminal to a circularly permuted COOH-NH2 ligase domain [1]. [1]. 20023723. Amidoligases with ATP-grasp, glutamine synthetase-like and acetyltransferase-like domains: synthesis of novel metabolites and peptide modifications of proteins. Iyer LM, Abhiman S, Maxwell Burroughs A, Aravind L;. Mol Biosyst. 2009;5:1636-1660. (from Pfam)

Date:

2024-10-16

alpha-E domain-containing protein with an uncharacterized alpha helical domain that includes a highly conserved ER motif and is typically found as a tandem duplication

Date:

2019-03-12