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Family 4 Glycosyltransferase in conflict systems
This entry corresponds to Family 4 Glycosyltransferase domain comprised of two Rossmann fold subdomains. The domain is found in architecturally-rich proteins of metazoan counter-invader systems and in bacterial conflict systems [1]. [1]. 34061031. Bacterial death and TRADD-N domains help define novel apoptosis and immunity mechanisms shared by prokaryotes and metazoans. Kaur G, Iyer LM, Burroughs AM, Aravind L;. Elife. 2021; [Epub ahead of print] (from Pfam)
glycosyltransferase
Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family. (from Pfam)
Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids. (from Pfam)
bifunctional glycosyltransferase containing N-terminal family 2 and C-terminal family 4 glycosyltransferase domains, catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds
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