Protein Family Models

This family represents the N-terminal region of the bacterial poly-beta-hydroxybutyrate polymerase (PhaC). Polyhydroxyalkanoic acids (PHAs) are carbon and energy reserve polymers produced in some bacteria when carbon sources are plentiful and another nutrient, such as nitrogen, phosphate, oxygen, or sulfur, becomes limiting. PHAs composed of monomeric units ranging from 3 to 14 carbons exist in nature. When the carbon source is exhausted, PHA is utilised by the bacterium. PhaC links D-(-)-3-hydroxybutyrl-CoA to an existing PHA molecule by the formation of an ester bond [1]. This family appears to be a partial segment of an alpha/beta hydrolase domain. [1]. 10427049. Cloning, molecular analysis, and expression of the. polyhydroxyalkanoic acid synthase (phaC) gene from. Chromobacterium violaceum.. Kolibachuk D, Miller A, Dennis D;. Appl Environ Microbiol 1999;65:3561-3565. (from Pfam)

Date:

2024-08-14

This catalytic domain is found in a very wide range of enzymes. [1]. 1409539. The alpha/beta hydrolase fold. Ollis DL, Cheah E, Cygler M, Dijkstra B, Frolow F, Franken SM,. Harel M, Remington SJ, Silman I, Schrag J, Sussman JL,. Verschueren KHG, Goldman A;. Protein Eng 1992;5:197-211. (from Pfam)

Date:

2024-08-14

This HMM represents the class I subfamily of poly(R)-hydroxyalkanoate synthases, which polymerizes hydroxyacyl-CoAs with three to five carbons in the hydroxyacyl backbone into aliphatic esters termed poly(R)-hydroxyalkanoic acids. These polymers accumulate as carbon and energy storage inclusions in many species and can amount to 90 percent of the dry weight of cell.

Gene:

phaC

Date:

2024-05-30

class I poly(R)-hydroxyalkanoic acid synthase similar to poly(3-hydroxyalkanoate) polymerase subunit PhaC, which polymerizes D(-)-3-hydroxybutyryl-CoA to produce polyhydroxybutyrate (PHB)

Date:

2020-02-28