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endonuclease/exonuclease/phosphatase family protein
This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g Swiss:P27695, DNase I proteins EC:3.1.21.1 e.g. Swiss:P24855, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 Swiss:O43426, Sphingomyelinase EC:3.1.4.12 Swiss:P11889 and Nocturnin Swiss:O35710. [1]. 10838565. Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. Dlakic M;. Trends Biochem Sci 2000;25:272-273. [2]. 7885481. Structure and function of the multifunctional DNA-repair enzyme exonuclease III. Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA;. Nature 1995;374:381-386. [3]. 1748997. DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex. Lahm A, Suck D;. J Mol Biol 1991;222:645-667. (from Pfam)
exodeoxyribonuclease III
exodeoxyribonuclease III is a Mg-dependent 3' to 5' exonuclease acting on dsDNA, which releases 5' phosphomononucleotides as degradation products
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