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AMP-binding enzyme
This is a small domain that is found C terminal to Pfam:PF00501. It has a central beta sheet core that is flanked by alpha helices. (from Pfam)
AMP-binding protein
(2,3-dihydroxybenzoyl)adenylate synthase EntE
(2,3-dihydroxybenzoyl)adenylate synthase
Member of this family of (2,3-dihydroxybenzoyl)adenylate synthases include EntE from enterobactin biosynthesis in E. coli and Salmonella, but also
(2,3-dihydroxybenzoyl)adenylate synthase catalyzes the activation of the carboxylate group of 2,3-dihydroxy-benzoate via a reversible ATP-dependent pyrophosphate exchange reactions to yield the acyladenylate intermediate (2,3-dihydroxybenzoyl)adenylate, such as in the biosynthesis of the siderophore enterobactin
Proteins in this family belong to the AMP-binding enzyme family (PF00501). Members activate 2,3-dihydroxybenzoate (DHB) by ligation of AMP from ATP with the release of pyrophosphate; many are involved in synthesis of siderophores such as enterobactin, vibriobactin, vulnibactin, etc. The most closely related proteine believed to differ in function activates salicylate rather than DHB.
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