Protein Family Models

This domain is found at the N-terminal region of Cyclic-di-AMP phosphodiesterase GdpP from Geobacillus thermodenitrificans. GdpP is a stress signaling protein with phosphodiesterase activity against cyclic-di-AMP (c-di-AMP). This protein contains three protein domains in addition to the two N-terminal transmembrane helices: a Per-ARNT-Sim (PAS) domain (this entry), a GGDEF domain, and a DHH/DHHA1 domain (Pfam:PF01368 and Pfam:PF02272). This domain adopts the typical alpha-beta-PAS domain fold formed by several short and distorted alpha-helices and one five-stranded antiparallel beta- sheet. Noticeably, three of the strands and one of the helices are shorter than those found in other typical PAS domains [1]. This domain is also found at the N-terminal of the membrane protein-large ribosomal subunit bL9 fusion protein from phytoplasma which have a large N-terminal domain structurally similar to this group of sequences, although not functionally related. Paper describing PDB structure 2m1c. [1]. 23504327. Solution structure of the PAS domain of a thermophilic YybT protein homolog reveals a potential ligand-binding site. Tan E, Rao F, Pasunooti S, Pham TH, Soehano I, Turner MS, Liew CW, Lescar J, Pervushin K, Liang ZX;. J Biol Chem. 2013;288:11949-11959. (from Pfam)

Date:

2025-01-31

It is predicted that this family of proteins all perform a phosphoesterase function. It included the single stranded DNA exonuclease RecJ. [1]. 9478130. A novel family of predicted phosphoesterases includes Drosophila prune protein and bacterial RecJ exonuclease. Aravind L, Koonin EV;. Trends Biochem Sci 1998;23:17-19. (from Pfam)

Date:

2025-02-01

DHHA1 ( DHH-associated domain) is often found with DHH, and is suggested to have an RNA-binding function.

Date:

2025-02-01

DHH family phosphoesterase such as Bacillus subtilis cyclic-di-AMP phosphodiesterase GdpP and Listeria monocytogenes cyclic-di-AMP phosphodiesterase PdeA

Date:

2018-06-13