Protein Family Models

This is a family of proteins that are flavin-dependent thymidylate synthases. [1]. 12029065. An alternative flavin-dependent mechanism for thymidylate synthesis. Myllykallio H, Lipowski G, Leduc D, Filee J, Forterre P, Liebl U;. Science. 2002;297:105-107. [2]. 15046578. Two distinct pathways for thymidylate (dTMP) synthesis in (hyper)thermophilic Bacteria and Archaea. Leduc D, Graziani S, Meslet-Cladiere L, Sodolescu A, Liebl U, Myllykallio H;. Biochem Soc Trans. 2004;32:231-235. [3]. 17890305. Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria. Leduc D, Escartin F, Nijhout HF, Reed MC, Liebl U, Skouloubris S, Myllykallio H;. J Bacteriol. 2007;189:8537-8545. (from Pfam)

Date:

2024-10-16

thymidylate synthase catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product

Date:

2024-11-05