Protein Family Models

YhjD and YihY are paralogs in Escherichia coli K-12. YhjD appears to have a transporter-like function in transporting lipid IV-A, a precursor of lipopolysaccharide (LPS). Mutation of BrkB in Bordetella pertussis increases serum resistance, which has led to it being called a virulence factor, but the finding would be consistent with a housekeeping role in cell envelope maintenance.

Date:

2024-10-16

YihY/virulence factor BrkB family protein similar to Bordetella pertussis BrkB, a virulence factor that is essential for resistance to complement-dependent killing by serum

Date:

2024-06-28

Initial identification of members of this protein family was based on characterization of the yihY gene product as ribonuclease BN in Escherichia coli. This identification has been withdrawn, as the group now finds the homolog in E. coli of RNase Z is the true ribonuclease BN rather than a strict functional equivalent of RNase Z. Members of this subfamily include the largely uncharacterized BrkB (Bordetella resist killing by serum B) from Bordetella pertussis. Some members have an additional C-terminal domain. Paralogs from E. coli (yhjD) and Mycobactrium tuberculosis (Rv3335c) are part of a smaller, related subfamily that form their own cluster.

Date:

2024-08-07