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transcriptional repressor
This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family. [1]. 9784364. Binding of the fur (ferric uptake regulator) repressor of Escherichia coli to arrays of the GATAAT sequence. Escolar L, Perez-Martin J, de Lorenzo V;. J Mol Biol 1998;283:537-547. (from Pfam)
peroxide-responsive transcriptional repressor PerR
PerR must bind Fe(2+) or Mn(2+) to act as a transcriptional repressor. When it is bound to Fe(2+), the presence of hydrogen peroxide leads to an iron-mediated histidine oxidation that leads to de-repression.
Fur family transcriptional regulator
Fur (ferric uptake regulator) family transcriptional regulator such as metal ion uptake regulator proteins, which are responsible for controlling the intracellular concentration of iron in many bacteria
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