Protein Family Models

This entry represents the first PDC (PhoQ/DcuS/CitA) sensor domain found in methyl-accepting chemotaxis proteins (MCPs) such as TLQP and MCPA/B. Paper describing PDB structure 3li8. [1]. 20435045. Structural characterization of the predominant family of histidine kinase sensor domains. Zhang Z, Hendrickson WA;. J Mol Biol. 2010;400:335-353. Paper describing PDB structure 4jgo. [2]. 23436677. Insight into the sporulation phosphorelay: crystal structure of the sensor domain of Bacillus subtilis histidine kinase, KinD. Wu R, Gu M, Wilton R, Babnigg G, Kim Y, Pokkuluri PR, Szurmant H, Joachimiak A, Schiffer M;. Protein Sci. 2013;22:564-576. Paper describing PDB structure 4wy9. [3]. 26923153. The crystal structure of the tandem-PAS sensing domain of Campylobacter jejuni chemoreceptor Tlp1 suggests indirect mechanism of ligand recognition. Machuca MA, Liu YC, Beckham SA, Gunzburg MJ, Roujeinikova A;. J Struct Biol. 2016;194:205-213. Paper describing PDB structure 4xmq. [4]. 26457436. Structural basis for amino-acid recognition and transmembrane signalling by tandem Per-Arnt-Sim (tandem PAS) chemoreceptor sensory domains. Liu YC, Machuca MA, Beckham SA, Gunzburg MJ, Roujeinikova A;. Acta Crystallogr D Biol Crystallogr. 2015;71:2127-2136. Paper describing PDB structure 5ave. [5]. 26878914. Identification of a Vibrio cholerae chemoreceptor that senses taurine and amino acids as attractants. Nishiyama S, Takahashi Y, Yamamoto K, Suzuki D, Itoh Y, Sumita K, Uchida Y, Homma M, Imada K, Kawagishi I;. Sci Rep. 2016;6:20866. (from Pfam)

Date:

2024-10-16

Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains [2]. This domain when present in chemoreceptors recognise several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognises C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043). [1]. 11084361. Cache - a signaling domain common to animal Ca(2+)-channel subunits and a class of prokaryotic chemotaxis receptors. Anantharaman V, Aravind L;. Trends Biochem Sci 2000;25:535-537. [2]. 27049771. Cache Domains That are Homologous to, but Different from PAS Domains Comprise the Largest Superfamily of Extracellular Sensors in Prokaryotes. Upadhyay AA, Fleetwood AD, Adebali O, Finn RD, Zhulin IB;. PLoS Comput Biol. 2016;12:e1004862. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs. [1]. 1601874. Sequence and characterization of Bacillus subtilis CheW. Hanlon DW, Marquez-Magana LM, Carpenter PB, Chamberlin MJ, Ordal GW;. J Biol Chem 1992;267:12055-12060. (from Pfam)

Date:

2024-10-16

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior; contains N-terminal Cache domain

Date:

2020-02-26