Protein Family Models

Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease [2]. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs [1]. [1]. 9778731. The great escape: structure and function of the autotransporter proteins. Henderson IR, Navarro-Garcia F, Nataro JP;. Trends Microbiol 1998;6:370-378. [2]. 3027577. Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease. Pohlner J, Halter R, Beyreuther K, Meyer TF;. Nature 1987;325:458-462. [3]. 11980709. Export of autotransported proteins proceeds through an oligomeric ring shaped by C-terminal domains. Veiga E, Sugawara E, Nikaido H, de Lorenzo V, Fernandez LA;. EMBO J 2002;21:2122-2131. [4]. 15014442. Structure of the translocator domain of a bacterial autotransporter. Oomen CJ, Van Ulsen P, Van Gelder P, Feijen M, Tommassen J, Gros P;. EMBO J 2004;23:1257-1266. (from Pfam)

Date:

2024-10-16

porin forms an aqueous channel for the diffusion of small hydrophilic molecules across the outer membrane

Date:

2024-08-07