Protein Family Models

This entry represents the central domain of the PaaX protein which are transcriptional regulators of protein involved in metabolism of phenylacetic acid. This domain is structurally related to the Cas2 ribonuclease domain, suggesting that these proteins may degrade mRNAs to carry out regulation. (from Pfam)

Date:

2024-10-16

This family contains proteins that are similar to the product of the paaX gene of Escherichia coli (Swiss:P76086). This protein is involved in the regulation of expression of a group of proteins known to participate in the metabolism of phenylacetic acid [1]. In fact, some members of this family are annotated by InterPro as containing a winged helix DNA-binding domain (Interpro:IPR009058). [1]. 10766858. Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. Ferrandez A, Garcia JL, Diaz E;. J Biol Chem 2000;275:12214-12222. (from Pfam)

Date:

2024-10-16

This family contains proteins that are similar to the product of the paaX gene of Escherichia coli (Swiss:P76086). This protein is involved in the regulation of expression of a group of proteins known to participate in the metabolism of phenylacetic acid [1]. [1]. 10766858. Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. Ferrandez A, Garcia JL, Diaz E;. J Biol Chem 2000;275:12214-12222. (from Pfam)

Date:

2024-10-16

PaaX_trns_reg family protein

Date:

2017-03-02

This transcriptional regulator is always found in association with operons believed to be involved in the degradation of phenylacetic acid [1]. The gene product has been shown to bind to the promoter sites and repress their transcription [2].

Gene:

paaX

Date:

2021-09-20