Protein Family Models

This is a family of DNA-binding proteins. Members of this family form homodimers which bind DNA via a tweezer-like structure [1-3]. The conformation of the DNA is changed when bound to these proteins [3]. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage [1]. [1]. 12486730. Crystal structure of YbaB from Haemophilus influenzae (HI0442), a protein of unknown function coexpressed with the recombinational DNA repair protein RecR. Lim K, Tempczyk A, Parsons JF, Bonander N, Toedt J, Kelman Z, Howard A, Eisenstein E, Herzberg O;. Proteins. 2003;50:375-379. [2]. 19594923. DNA-binding by Haemophilus influenzae and Escherichia coli YbaB, members of a widely-distributed bacterial protein family. Cooley AE, Riley SP, Kral K, Miller MC, DeMoll E, Fried MG, Stevenson B;. BMC Microbiol. 2009;9:13. [3]. 19208644. Borrelia burgdorferi EbfC defines a newly-identified, widespread family of bacterial DNA-binding proteins. Riley SP, Bykowski T, Cooley AE, Burns LH, Babb K, Brissette CA, Bowman A, Rotondi M, Miller MC, DeMoll E, Lim K, Fried MG, Stevenson B;. Nucleic Acids Res. 2009;37:1973-1983. (from Pfam)

Date:

2024-10-16

YbaB/EbfC family nucleoid-associated protein is a DNA-binding protein that may be involved in DNA repair

Date:

2024-10-03

The role of this DNA-binding protein is unknown, but it has been expressed and crystallized. Its gene nearly always occurs next to recR and/or dnaX. It is restricted to Bacteria and the plant Arabidopsis. The plant form contains an additional N-terminal region that may serve as a transit peptide and shows a close relationship to the cyanobacterial member, suggesting that it is a chloroplast protein. Members of this family are found in a single copy per bacterial genome, but are broadly distributed. A member is present even in the minimal gene complement of Mycoplasm genitalium.

Date:

2024-08-07