Protein Family Models

The MgrB protein is a short lipoprotein. The mgrB gene has a mg2+ responsive promoter [1]. Deletion of mgrB results in a potent increase in PhoP-regulated transcription [3]. The PhoQ/PhoP signaling system responds to low magnesium and the presence of certain cationic antimicrobial peptides. Over-expression of mgrB decreased transcription at both high and low concentrations of magnesium. Localization and bacterial two-hybrid studies suggest that MgrB resides in the inner-membrane and interacts directly with PhoQ. This domain family is found in bacteria, and is approximately 40 amino acids in length. There are two conserved sequence motifs: CDQ and GIC. [1]. 10464230. Molecular characterization of the PhoP-PhoQ two-component system in Escherichia coli K-12: identification of extracellular Mg2+-responsive promoters. Kato A, Tanabe H, Utsumi R;. J Bacteriol. 1999;181:5516-5520. [2]. 17909183. Stimulus-dependent differential regulation in the Escherichia coli PhoQ PhoP system. Miyashiro T, Goulian M;. Proc Natl Acad Sci U S A. 2007;104:16305-16310. [3]. 20041203. Feedback inhibition in the PhoQ/PhoP signaling system by a membrane peptide. Lippa AM, Goulian M;. PLoS Genet. 2009;5:e1000788. (from Pfam)

Gene:

mgrB

Date:

2024-10-16

Gene:

mgrB

Date:

2023-10-26

PhoP/PhoQ regulator MgrB represses PhoP/PhoQ signaling, possibly by binding to the periplasmic domain of PhoQ, altering its activity and that of downstream effector PhoP

Date:

2023-12-13