Protein Family Models

This entry represents the YcgR-like domain found at the N-terminal of MrkH (Swiss:G3FT00) from Klebsiella pneumoniae and similar sequences [1] which contain a PilZ domain at the C-terminal. MrkH is a c-di-GMP-related transcriptional regulator that affects type 3 fimbrial expression in response to cellular c-di-GMP level, playing and important role in biofilm formation. This protein binds to the promoter regulation fragments of mrkHI and mrkA mainly through its PilZ domain and this YcgR-like domain also participates in DNA-binding [1]. Paper describing PDB structure 5ejl. [1]. 27650952. The PilZ domain of MrkH represents a novel DNA binding motif. Wang F, He Q, Su K, Gao F, Huang Y, Lin Z, Zhu D, Gu L;. Protein Cell. 2016;7:766-772. (from Pfam)

Date:

2024-10-16

flagellar brake protein, similar to YcgR, which is known to interact with the flagellar switch-complex proteins FliG and FliM, resulting in a reduction of torque generation and induction of CCW motor bias; it does this in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner via its PilZ domain

Date:

2018-10-15