Protein Family Models

This is a family of Gram-negative bacterial outer membrane lipoproteins. LpoB is required for the function of the major peptidoglycan synthase enzyme PBP1B. It interacts with PBP1B protein via the UvrB-like non-catalytic domain on that protein. LpoB has a 54-aa-long flexible N-terminal stretch followed by a globular domain with similarity to the N-terminal domain of the prevalent periplasmic protein TolB. The long, flexible N-terminal region of LpoB enables it to span the periplasm and reach its docking site in PBP1B. Peptidoglycan is the essential polymer within the sacculus that surrounds the cytoplasmic membrane of bacteria [1]. [1]. 24821816. Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B. Egan AJ, Jean NL, Koumoutsi A, Bougault CM, Biboy J, Sassine J, Solovyova AS, Breukink E, Typas A, Vollmer W, Simorre JP;. Proc Natl Acad Sci U S A. 2014;111:8197-8202. (from Pfam)

Date:

2024-10-16

TolB is an essential periplasmic component of the tol-dependent translocation system. This function of this amino terminal domain is uncertain. [1]. 10673426. The structure of TolB, an essential component of the tol-dependent translocation system, and its protein-protein interaction with the translocation domain of colicin E9. Carr S, Penfold CN, Bamford V, James R, Hemmings AM. Structure Fold Des 2000;8:57-66. (from Pfam)

Date:

2024-10-16

CsgG is an outer membrane-located lipoprotein that is highly resistant to protease digestion. During curli assembly, an adhesive surface fibre, CsgG is required to maintain the stability of CsgA and CsgB [1]. [1]. 9383186. Availability of the fibre subunit CsgA and the nucleator protein CsgB during assembly of fibronectin-binding curli is limited by the intracellular concentration of the novel lipoprotein CsgG. Loferer H, Hammar M, Normark S;. Mol Microbiol 1997;26:11-23. (from Pfam)

Date:

2024-10-16

CsgG/HfaB family protein similar to Caulobacter HfaB, which is involved in attachment of the holdfast, a polysaccharide complex adhesive organelle, to the cell, and to CsgG, a lipoprotein that forms a secretion channel for curli subunits, functional amyloids involved in biofilm formation, in the outer membrane

Date:

2020-02-11