Protein Family Models

This family catalyses the final step in the elongation factor P modification pathway. It hydroxylates Lys-34 of elongation factor P [1]. Members of this family have a conserved HEXXH motif, suggesting they are putative peptidases of zincin fold [2]. [1]. 22706199. Lys34 of translation elongation factor EF-P is hydroxylated by YfcM. Peil L, Starosta AL, Virumae K, Atkinson GC, Tenson T, Remme J, Wilson DN;. Nat Chem Biol. 2012;8:695-697. [2]. 23671590. CLCAs - A Family of Metalloproteases of Intriguing Phylogenetic Distribution and with Cases of Substituted Catalytic Sites. Lenart A, Dudkiewicz M, Grynberg M, Pawlowski K;. PLoS One. 2013;8:e62272. (from Pfam)

Date:

2024-10-16

elongation factor P hydroxylase is involved in the final hydroxylation step of the post-translational modification of translation elongation factor P (EF-P) on a conserved lysine

Date:

2016-02-02