This family contains a number of eukaryotic etoposide-induced 2.4 (EI24) proteins approximately 350 residues long as well as bacterial CysZ proteins (formerly known as DUF540). In cells treated with the cytotoxic drug etoposide, EI24 is induced by p53 [1]. It has been suggested to play an important role in negative cell growth control [2]. [1]. 8649819. Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells. Lehar SM, Nacht M, Jacks T, Vater CA, Chittenden T, Guild BC;. Oncogene 1996;12:1181-1187. [2]. 10594026. ei24, a p53 response gene involved in growth suppression and apoptosis. Gu Z, Flemington C, Chittenden T, Zambetti GP;. Mol Cell Biol 2000;20:233-241. [3]. 29792261. Structure-based analysis of CysZ-mediated cellular uptake of sulfate. Assur Sanghai Z, Liu Q, Clarke OB, Belcher-Dufrisne M, Wiriyasermkul P, Giese MH, Leal-Pinto E, Kloss B, Tabuso S, Love J, Punta M, Banerjee S, Rajashankar KR, Rost B, Logothetis D, Quick M, Hendrickson WA, Mancia F;. Elife. 2018;7:e27829. (from Pfam)
- Date:
- 2024-10-16