Protein Family Models for Protein (Select 512463721) - Protein Family Models

Select item 4240241.

This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold. (from Pfam)

GO Terms:

Molecular Function:: ATP binding (GO:0005524)

Molecular Function:: hydrolase activity (GO:0016787)

Date:: 2024-08-14

Family Accession:: NF024754.5
Method:: HMM

Select item 4221642.

AAA family ATPase

Date:: 2024-08-14

Family Accession:: NF024642.5
Method:: HMM

Select item 4112213.

UvrD-helicase domain-containing protein

The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyse ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family. Structure of Swiss:P09980. [1]. 9288744. Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP. Korolev S, Hsieh J, Gauss GH, Lohman TM, Waksman G;. Cell 1997;90:635-647. (from Pfam)

GO Terms:

Molecular Function:: ATP binding (GO:0005524)

Date:: 2024-10-16

Family Accession:: NF012789.5
Method:: HMM

Select item 4111034.

HRDC domain-containing protein

The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains [4]. [1]. 9397680. A putative nucleic acid-binding domain in Bloom's and Werner's syndrome helicases. Morozov V, Mushegian AR, Koonin EV, Bork P;. Trends Biochem Sci 1997;22:417-418. [2]. 15990871. The HRDC domain of BLM is required for the dissolution of double Holliday junctions. Wu L, Chan KL, Ralf C, Bernstein DA, Garcia PL, Bohr VA, Vindigni A, Janscak P, Keck JL, Hickson ID;. EMBO J. 2005;24:2679-2687. [3]. 10647186. The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins. Liu Z, Macias MJ, Bottomley MJ, Stier G, Linge JP, Nilges M, Bork P, Sattler M;. Structure. 1999;7:1557-1566. [4]. 17085080. Three tandem HRDC domains have synergistic effect on the RecQ functions in Deinococcus radiodurans. Huang L, Hua X, Lu H, Gao G, Tian B, Shen B, Hua Y;. DNA Repair (Amst). 2006; [Epub ahead of print] (from Pfam)

GO Terms:

Molecular Function:: nucleic acid binding (GO:0003676)

Date:: 2024-10-16

Family Accession:: NF012779.5
Method:: HMM

Select item 4000095.