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Cro/CI family transcriptional regulator
Bacteriophage P22 Cro protein represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operator-regions normally used by the repressor protein for lysogenic maintenance. [1]. 3954988. Bacteriophage P22 Cro protein: sequence, purification, and properties. Poteete AR, Hehir K, Sauer RT;. Biochemistry. 1986;25:251-256. [2]. 15062080. Secondary structure switching in Cro protein evolution. Newlove T, Konieczka JH, Cordes MH;. Structure. 2004;12:569-581. [3]. 18369196. N15 Cro and lambda Cro: orthologous DNA-binding domains with completely different but equally effective homodimer interfaces. Dubrava MS, Ingram WM, Roberts SA, Weichsel A, Montfort WR, Cordes MH;. Protein Sci. 2008;17:803-812. (from Pfam)
Cro/CI family transcriptional regulator similar to Salmonella virus P22 regulatory protein cro that is necessary for the late stage of lytic growth
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