Protein Family Models

MenC (o-succinylbenzoate synthase OSBS converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB). It belongs to the enolase superfamily [1-4]. This entry represents the N-terminal domain of MenC. Paper describing PDB structure 1fhu. [1]. 10978150. Evolution of enzymatic activity in the enolase superfamily: structure of o-succinylbenzoate synthase from Escherichia coli in complex with Mg2+ and o-succinylbenzoate. Thompson TB, Garrett JB, Taylor EA, Meganathan R, Gerlt JA, Rayment I;. Biochemistry. 2000;39:10662-10676. Paper describing PDB structure 1r6w. [2]. 14661953. Evolution of enzymatic activity in the enolase superfamily: structural and mutagenic studies of the mechanism of the reaction catalyzed by o-succinylbenzoate synthase from Escherichia coli. Klenchin VA, Taylor Ringia EA, Gerlt JA, Rayment I;. Biochemistry. 2003;42:14427-14433. Paper describing PDB structure 2ofj. [3]. 17503785. Stability for function trade-offs in the enolase superfamily "catalytic module". Nagatani RA, Gonzalez A, Shoichet BK, Brinen LS, Babbitt PC;. Biochemistry. 2007;46:6688-6695. Paper describing PDB structure 2ozt. [4]. 24872444. Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family. Odokonyero D, Sakai A, Patskovsky Y, Malashkevich VN, Fedorov AA, Bonanno JB, Fedorov EV, Toro R, Agarwal R, Wang C, Ozerova ND, Yew WS, Sauder JM, Swaminathan S, Burley SK, Almo SC, Glasner ME;. Proc Natl Acad Sci U S A. 2014;111:8535-8540. (from Pfam)

Date:

2024-10-16

This domain appears at the C-terminus of many of the proteins that carry the MR_MLE_N Pfam:PF02746 domain. EC:4.2.1.40. (from Pfam)

Date:

2024-08-14

o-succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway

Date:

2017-02-03

Catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate

Gene:

menC

Date:

2021-08-24

This model describes the enzyme o-succinylbenzoic acid synthetase (menC) that is involved in one of the steps of the menaquinone biosynthesis pathway. It takes SHCHC and makes it into 2-succinylbenzoate. Included in this model are gamma proteobacteria and archaea. Many of the com-names of the proteins identified by the model are identified as O-succinylbenzoyl-CoA synthase in error.

Gene:

menC

Date:

2021-04-27