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2-oxoglutarate dehydrogenase family protein
2-oxoglutarate dehydrogenase family protein, such as 2-oxoglutarate dehydrogenase subunit E1 that catalyzes the decarboxylation of 2-oxoglutarate and the formation of TPP-hydroxysuccinate
2-oxoglutarate dehydrogenase E1 subunit family protein
This domain is found at the N-terminus of 2-oxoglutarate dehydrogenases. (from Pfam)
2-oxoglutarate dehydrogenase C-terminal
OxoGdeHyase_C is a family found immediately C-terminal to Transket_pyr, Pfam:PF02779. It is found at the C-terminus of 2-oxoglutarate dehydrogenase. (from Pfam)
Transketolase, pyrimidine binding domain
This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases. [1]. 8176731. Refined structure of transketolase from Saccharomyces cerevisiae at 2.0 A resolution. Nikkola M, Lindqvist Y, Schneider G;. J Mol Biol 1994;238:387-404. [2]. 1628611. Three-dimensional structure of transketolase, a thiamine diphosphate dependent enzyme, at 2.5 A resolution. Lindqvist Y, Schneider G, Ermler U, Sundstrom M;. EMBO J 1992;11:2373-2379. (from Pfam)
thiamine pyrophosphate-dependent enzyme
This family uses thiamine pyrophosphate as a cofactor. This family includes pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase and 2-oxoisovalerate dehydrogenase. (from Pfam)
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate
2-oxoglutarate dehydrogenase E1 component
The 2-oxoglutarate dehydrogenase complex consists of this thiamine pyrophosphate-binding subunit (E1), dihydrolipoamide succinyltransferase (E2), and lipoamide dehydrogenase (E3). The E1 ortholog from Corynebacterium glutamicum is unusual in having an N-terminal extension that resembles the dihydrolipoamide succinyltransferase (E2) component of 2-oxoglutarate dehydrogenase.
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