Protein Family Models

This family of bacterial proteins includes a sodium-translocating NADH-ubiquinone oxidoreductase (i.e. a respiration linked sodium pump). In Vibrio cholerae, it negatively regulates the expression of virulence factors through inhibiting (by an unknown mechanism) the transcription of the transcriptional activator ToxT [1]. The family also includes proteins involved in nitrogen fixation, RnfD and RnfE. The similarity of these proteins to NADH-ubiquinone oxidoreductases was previously noted [2]. [1]. 10077658. Effects of changes in membrane sodium flux on virulence gene expression in Vibrio cholerae. Hase CC, Mekalanos JJ;. Proc Natl Acad Sci U S A 1999;96:3183-3187. [2]. 9154934. Membrane localization, topology, and mutual stabilization of the rnfABC gene products in Rhodobacter capsulatus and implications for a new family of energy-coupling NADH oxidoreductases. Kumagai H, Fujiwara T, Matsubara H, Saeki K;. Biochemistry 1997;36:5509-5521. (from Pfam)

Date:

2024-10-16

This HMM represents the NqrB subunit of the six-protein, Na(+)-pumping NADH-quinone reductase of a number of marine and pathogenic Gram-negative bacteria. This oxidoreductase complex functions primarily as a sodium ion pump [1].

Gene:

nqrB

Date:

2024-06-11

Na+-translocating NADH-quinone reductase subunit B, a component of the complex that uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm

Date:

2015-11-02

Date:

2022-10-11