Protein Family Models

The ACT domain is a structural motif of 70-90 amino acids that functions in the control of metabolism, solute transport and signal transduction. They are thus found in a variety of different proteins in a variety of different arrangements [1]. In mammalian phenylalanine hydroxylase the domain forms no contacts but promotes an allosteric effect despite the apparent lack of ligand binding [2]. [1]. 16987805. The ACT domain: a small molecule binding domain and its role as a common regulatory element. Grant GA;. J Biol Chem. 2006;281:33825-33829. [2]. 18368466. Searching distant homologs of the regulatory ACT domain in phenylalanine hydroxylase. Siltberg-Liberles J, Martinez A;. Amino Acids. 2009;36:235-249. (from Pfam)

Date:

2024-10-16

This domain, found in various hypothetical bacterial proteins, has no known function. However, its structure is similar to the ACT domain which suggests that it binds to amino acids and regulates other protein activity. This family was formerly known as DUF2241. (from Pfam)

Date:

2024-08-14

ACT domain-containing protein

Date:

2019-07-15