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Phosphoribosyl-ATP pyrophosphohydrolase
This enzyme catalyses the second step in the histidine biosynthetic pathway. [1]. 379004. The product of the his4 gene cluster in Saccharomyces cerevisiae. A trifunctional polypeptide. Keesey JK Jr, Bigelis R, Fink GR;. J Biol Chem 1979;254:7427-7433. [2]. 3528746. Primary and secondary structural homologies between the HIS4 gene product of Saccharomyces cerevisiae and the hisIE and hisD gene products of Escherichia coli and Salmonella typhimurium. Bruni CB, Carlomagno MS, Formisano S, Paolella G;. Mol Gen Genet 1986;203:389-396. (from Pfam)
nucleoside triphosphate pyrophosphohydrolase
MazG family nucleoside triphosphate (NTP) pyrophosphohydrolase catalyzes the hydrolysis of an NTP, such as ITP, GTP, CTP and UTP, to form the corresponding NMP and diphosphate
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