Members of this family have serine hydrolase activity. They contain a conserved serine hydrolase motif, GXSXG/A, where the serine is a putative nucleophile [1]. This family has an alpha-beta hydrolase fold [2,3]. Eukaryotic members of this family have a conserved LXCXE motif, which binds to retinoblastomas. This motif is absent from prokaryotic members of this family [3]. [1]. 20080647. RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia. Shields DJ, Niessen S, Murphy EA, Mielgo A, Desgrosellier JS, Lau SK, Barnes LA, Lesperance J, Bouvet M, Tarin D, Cravatt BF, Cheresh DA;. Proc Natl Acad Sci U S A. 2010;107:2189-2194. [2]. 15159570. Harvesting the high-hanging fruit: the structure of the YdeN gene product from Bacillus subtilis at 1.8 angstroms resolution. Janda I, Devedjiev Y, Cooper D, Chruszcz M, Derewenda U, Gabrys A, Minor W, Joachimiak A, Derewenda ZS;. Acta Crystallogr D Biol Crystallogr 2004;60:1101-1107. [3]. 19004028. Crystal structure of human retinoblastoma binding protein 9. Vorobiev SM, Su M, Seetharaman J, Huang YJ, Chen CX, Maglaqui M, Janjua H, Proudfoot M, Yakunin A, Xiao R, Acton TB, Montelione GT, Tong L;. Proteins. 2009;74:526-529. (from Pfam)
GO Terms:- Molecular Function:
- hydrolase activity (GO:0016787)
- Date:
- 2024-10-16