Protein Family Models

This domain is related to other HNH domain families such as Pfam:PF01844. Suggesting that these proteins have a nucleic acid cleaving function. (from Pfam)

Date:

2024-08-14

His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity [4]. Named family as HNH. [1]. 7817395. Amino acid sequence motif of group I intron endonucleases is conserved in open reading frames of group II introns. Shub DA, Goodrich-Blair H, Eddy SR;. Trends Biochem Sci 1994;19:402-404. Extended HNH family. [2]. 9358175. Statistical modeling and analysis of the LAGLIDADG family of site-specific endonucleases and identification of an intein that encodes a site-specific endonuclease of the HNH family. Dalgaard JZ, Klar AJ, Moser MJ, Holley WR, Chatterjee A, Mian IS;. Nucleic Acids Res 1997;25:4626-4638. Named family as EX1HH-HX3H. [3]. 7920259. Self-splicing group I and group II introns encode homologous (putative) DNA endonucleases of a new family. Gorbalenya AE;. Protein Sci 1994;3:1117-1120. [4]. 27131500. Biochemical characterization of a thermostable HNH endonuclease from deep-sea thermophilic bacteriophage GVE2. Zhang L, Huang Y, Xu D, Yang L, Qian K, Chang G, Gong Y, Zhou X, Ma K;. Appl Microbiol Biotechnol. 2016;100:8003-8012. (from Pfam)

Date:

2024-10-16

HNH endonuclease contains an HNH endonuclease signature motif and may catalyze the hydrolysis of DNA

Date:

2024-05-06