Protein Family Models

Date:

2024-08-14

This domain is found in a group of putative heme-iron utilisation proteins, such as HugZ. It can also be found in C-terminal of the glutamyl-tRNA reductase-binding (GluTRBP) protein from Arabidopsis [1]. GluTRBP is involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in heme and chlorophyll biosynthesis [2]. GluTRBP is necessary for efficient photosynthetic electron transport in chloroplasts [3]. [1]. 24753615. Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its stimulator protein. Zhao A, Fang Y, Chen X, Zhao S, Dong W, Lin Y, Gong W, Liu L;. Proc Natl Acad Sci U S A. 2014;111:6630-6635. [2]. 22180625. An Arabidopsis GluTR binding protein mediates spatial separation of 5-aminolevulinic acid synthesis in chloroplasts. Czarnecki O, Hedtke B, Melzer M, Rothbart M, Richter A, Schroter Y, Pfannschmidt T, Grimm B;. Plant Cell. 2011;23:4476-4491. [3]. 20657737. Arabidopsis thaliana PGR7 encodes a conserved chloroplast protein that is necessary for efficient photosynthetic electron transport. Jung HS, Okegawa Y, Shih PM, Kellogg E, Abdel-Ghany SE, Pilon M, Sjolander K, Shikanai T, Niyogi KK;. PLoS One. 2010;5:e11688. (from Pfam)

Date:

2024-10-16

Family of domains with putative PNPOx function. Family members were predicted to encode pyridoxamine 5'-phosphate oxidase, based on sequence similarity. However, there is no experimental data to validate the predicted activity and purified proteins, such as Swiss:Q06199 and its paralogs, do not possess this activity, nor do they bind to flavin mononucleotide (FMN). To date, the only time functional oxidase activity has been experimentally demonstrated is when the sequences contain both Pfam:PF01243 and Pfam:PF10590. Moreover, some of the family members that contain both domains have been shown to be involved in phenazine biosynthesis. While some molecular function has been experimentally validated for the proteins containing both domains, the role performed by each domain on its own is unknown [1]. [1]. 26327315. Experimental Evidence for a Revision in the Annotation of Putative Pyridoxamine 5'-Phosphate Oxidases P(N/M)P from Fungi. Domitrovic T, Raymundo DP, da Silva TF, Palhano FL;. PLoS One. 2015;10:e0136761. (from Pfam)

Date:

2024-10-16

HugZ family protein of unknown function, similar to Nostoc sp. putative heme oxygenase (Alr5027)

Date:

2018-04-14