Protein Family Models

This domain is found at the C-terminal end of Transcriptional regulator (TetR/AcrR family) from Thermus thermophilus (SbtR) [2] and similar sequences predominantly found in actinobacteria. This domain is found associated with Pfam:PF00440. Paper describing PDB structure 2q24. [1]. 21625866. Crystal structure of a putative transcriptional regulator SCO0520 from Streptomyces coelicolor A3(2) reveals an unusual dimer among TetR family proteins. Filippova EV, Chruszcz M, Cymborowski M, Gu J, Savchenko A, Edwards A, Minor W;. J Struct Funct Genomics. 2011;12:149-157. Paper describing PDB structure 3vuq. [2]. 23408580. Structure and function of a TetR family transcriptional regulator, SbtR, from thermus thermophilus HB8. Agari Y, Sakamoto K, Yutani K, Kuramitsu S, Shinkai A;. Proteins. 2013;81:1166-1178. Paper describing PDB structure 5ovy. [3]. 29675007. Mechanistic and Structural Insights Into the Unique TetR-Dependent Regulation of a Drug Efflux Pump in Mycobacterium abscessus. Richard M, Gutierrez AV, Viljoen AJ, Ghigo E, Blaise M, Kremer L;. Front Microbiol. 2018;9:649. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

TetR/AcrR family transcriptional regulator may control genes involved in one of a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Date:

2024-04-09