Protein Family Models

This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains. (from Pfam)

Date:

2024-08-14

This domain is found in the FtsH family of proteins. FtsH is the only membrane-bound ATP-dependent protease universally conserved in prokaryotes ([1]). It only efficiently degrades proteins that have a low thermodynamic stability - e.g. it lacks robust unfoldase activity. This feature may be key and implies that this could be a criterion for degrading a protein. In Oenococcus oeni FtsH is involved in protection against environmental stress ([2]), and shows increased expression under heat or osmotic stress. These two lines of evidence suggest that it is a fundamental prokaryotic self-protection mechanism that checks if proteins are correctly folded (personal obs: Yeats C). The precise function of this N-terminal region is unclear. [1]. 12667449. Lack of a robust unfoldase activity confers a unique level of substrate specificity to the universal AAA protease FtsH. Herman C, Prakash S, Lu CZ, Matouschek A, Gross CA;. Mol Cell 2003;11:659-669. [2]. 12732516. The ftsH gene of the wine bacterium Oenococcus oeni is involved in protection against environmental stress. Bourdineaud JP, Nehme B, Tesse S, Lonvaud-Funel A;. Appl Environ Microbiol 2003;69:2512-2520. (from Pfam)

Date:

2024-10-16

This Pfam entry includes some of the AAA proteins not detected by the Pfam:PF00004 model. [1]. 7646486. A 200-amino acid ATPase module in search of a basic function. Confalonieri F, Duguet M;. Bioessays 1995;17:639-650. A large extension of the family. [2]. 9927482. AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Neuwald AF, Aravind L, Spouge JL, Koonin EV;. Genome Res 1999;9:27-43. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2]. [1]. 7646486. A 200-amino acid ATPase module in search of a basic function. Confalonieri F, Duguet M;. Bioessays 1995;17:639-650. A large extension of the family. [2]. 9927482. AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Neuwald AF, Aravind L, Spouge JL, Koonin EV;. Genome Res 1999;9:27-43. (from Pfam)

Date:

2024-10-16

FtsH, a hexamer-forming membrane-anchored metalloprotease, belongs to the AAA family of ATPases and uses ATP for unfolding rather than to drive proteolysis directly. Substrates include damaged or misfolded proteins, as FtsH works in membrane protein quality control, but also specific substrates targeted for degradation by various regulatory circuits. FtsH was known historically as a cell division protein, and the designation HflB was used at one time, but is not currently favored.

Gene:

ftsH

Date:

2024-05-30

ATP-dependent metallopeptidase FtsH/Yme1/Tma family protein such as ATP-dependent zinc metalloprotease FtsH, which targets both cytoplasmic and membrane proteins and plays a role in quality control of integral membrane proteins

Date:

2024-04-19