Protein Family Models

This entry represents the C-terminal domain of Tyrosine--tRNA ligases which contains the S4 motif that binds RNA [1-5]. Paper describing PDB structure 1fjg. [1]. 11014183. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Carter AP, Clemons WM, Brodersen DE, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V;. Nature. 2000;407:340-348. Paper describing PDB structure 1fka. [2]. 11007480. Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution. Schluenzen F, Tocilj A, Zarivach R, Harms J, Gluehmann M, Janell D, Bashan A, Bartels H, Agmon I, Franceschi F, Yonath A;. Cell. 2000;102:615-623. Paper describing PDB structure 1i94. [3]. 11296217. Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3. Pioletti M, Schlunzen F, Harms J, Zarivach R, Gluhmann M, Avila H, Bashan A, Bartels H, Auerbach T, Jacobi C, Hartsch T, Yonath A, Franceschi F;. EMBO J. 2001;20:1829-1839. Paper describing PDB structure 1jh3. [4]. 12005430. Structure and dynamics of the anticodon arm binding domain of Bacillus stearothermophilus Tyrosyl-tRNA synthetase. Guijarro JI, Pintar A, Prochnicka-Chalufour A, Guez V, Gilquin B, Bedouelle H, Delepierre M;. Structure. 2002;10:311-317. Paper describing PDB structure 1jii. [5]. 11567092. Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors. Qiu X, Janson CA, Smith WW, Green SM, McDevitt P, Johanson K, Carter P, Hibbs M, Lewis C, Chalker A, Fosberry A, Lalonde J, Berge J, Brown P, Houge-Frydrych CS, Jarvest RL;. Protein. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-16

The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation [1]. The S4 domain probably mediates binding to RNA. [1]. 10093218. Novel predicted RNA-binding domains associated with the translation machinery. Aravind L, Koonin EV;. J Mol Evol 1999;48:291-302. [2]. 9707415. The crystal structure of ribosomal protein S4 reveals a two-domain molecule with an extensive RNA-binding surface: one domain shows structural homology to the ETS DNA-binding motif. Davies C, Gerstner RB, Draper DE, Ramakrishnan V, White SW;. EMBO J 1998;17:4545-4558. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

tyrosine--tRNA ligase catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)

Date:

2024-04-09

This HMM for tyrosine--tRNA ligase identifies proteins with a deep split between two groups. One group contains bacterial and organellar eukaryotic examples. The other contains archaeal and cytosolic eukaryotic examples.

Gene:

tyrS

Date:

2024-05-15