Protein Family Models

This is the C-terminal domain of the EscN protein family of ATPases that form part of the Type III secretion system (T3SS) present in Escherichia coli. T3SS is a macromolecular complex that creates a syringe-like apparatus extending from the bacterial cytosol across three membranes to the eukaryotic cytosol. This process is essential for pathogenicity. EscN is a functionally unique ATPase that provides an inner-membrane recognition gate for the T3SS chaperone-virulence effector complexes as well as a potential source of energy for their subsequent secretion.The C-terminal domain of T3SS ATPases mediates binding with multiple contact points along the chaperone [1]. [1]. 17237797. Structural analysis of a prototypical ATPase from the type III secretion system. Zarivach R, Vuckovic M, Deng W, Finlay BB, Strynadka NC;. Nat Struct Mol Biol. 2007;14:131-137. [2]. 17202259. Structural similarity between the flagellar type III ATPase FliI and F1-ATPase subunits. Imada K, Minamino T, Tahara A, Namba K;. Proc Natl Acad Sci U S A. 2007;104:485-490. (from Pfam)

Date:

2024-10-16

This entry includes the ATP synthase alpha and beta subunits, the ATP synthase associated with flagella and the termination factor Rho. [1]. 8065448. Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria. Abrahams JP, Leslie AG, Lutter R, Walker JE;. Nature 1994;370:621-628. [2]. 9261073. The crystal structure of the nucleotide-free alpha 3 beta 3 subcomplex of F1-ATPase from the thermophilic Bacillus PS3 is a symmetric trimer. Shirakihara Y, Leslie AG, Abrahams JP, Walker JE, Ueda T, Sekimoto Y, Kambara M, Saika K, Kagawa Y, Yoshida M;. Structure 1997;5:825-836. (from Pfam)

Date:

2024-10-16

Gene:

vscN2

Date:

2021-10-21