Protein Family Models

These probable extra-cytoplasmic solute receptors are strongly overrepresented in several beta-proteobacteria [1]. This family, formerly known as Bug - Bordetella uptake gene (bug) product - is a family of bacterial tripartite tricarboxylate receptors of the extracytoplasmic solute binding receptor-dependent transporter group of families, distinct from the ABC and TRAP-T families [3]. The TctABC system has been characterised in S. typhimurium [2], and TctC is the extracytoplasmic tricarboxylate-binding receptor which binds the transporters TctA and TctB, two integral membrane proteins. Complete three-component systems are found only in bacteria [2]. [1]. 12562821. Overrepresentation of a gene family encoding extracytoplasmic solute receptors in Bordetella. Antoine R, Jacob-Dubuisson F, Drobecq H, Willery E, Lesjean S, Locht C;. J Bacteriol 2003;185:1470-1474. [2]. 14499931. The tripartite tricarboxylate transporter (TTT) family. Winnen B, Hvorup RN, Saier MH Jr;. Res Microbiol. 2003;154:457-465. [3]. 6141166. Tricarboxylate-binding proteins of Salmonella typhimurium. Purification, crystallization, and physical properties. Sweet GD, Kay CM, Kay WW;. J Biol Chem. 1984;259:1586-1592. (from Pfam)

Date:

2024-10-16

Bug (Bordetella uptake gene) family tripartite tricarboxylate transporter (TTT) substrate binding protein is a periplasmic solute-binding (PBP) receptor that is a component of a TTT

Date:

2024-04-18