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NrtR DNA-binding winged helix domain-containing protein
This entry represents the C-terminal DNA-binding domain of bacterial transcriptional regulator NrtR which is involved in regulating the transcription of NAD biosynthetic genes. This domain has a winged helix-turn-helix structure [1]. Paper describing PDB structure 3gz5. [1]. 19604474. Structure and function of an ADP-ribose-dependent transcriptional regulator of NAD metabolism. Huang N, De Ingeniis J, Galeazzi L, Mancini C, Korostelev YD, Rakhmaninova AB, Gelfand MS, Rodionov DA, Raffaelli N, Zhang H;. Structure. 2009;17:939-951. Paper describing PDB structure 5bs6. [2]. 26438537. A novel transcriptional regulator of L-arabinose utilization in human gut bacteria. Chang C, Tesar C, Li X, Kim Y, Rodionov DA, Joachimiak A;. Nucleic Acids Res. 2015;43:10546-10559. (from Pfam)
NUDIX domain-containing protein
NUDIX hydrolase
NUDIX hydrolase catalyzes the hydrolysis of nucleoside diphosphates linked to other moieties (X); it requires a divalent cation, such as Mg2+ or Mn2+ for its activity
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