Protein Family Models for Protein (Select 519024890) - Protein Family Models

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Items: 5

Select item 4188881.

L-histidine N(alpha)-methyltransferase

The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic gene cluster. EGTD is the histidine methyltransferase that transfers three methyl groups to the alpha-amino moiety of histidine, in the first stage of the production of this histidine betaine derivative that carries a thiol group attached to the C2 atom of an imidazole ring [1]. [1]. 20420449. In vitro reconstitution of Mycobacterial ergothioneine biosynthesis. Seebeck FP;. J Am Chem Soc. 2010;132:6632-6633. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF021530.5
Method:: HMM

Select item 3953272.

new record, indexing in progress

Family Accession:

Select item 3546083.

new record, indexing in progress

Family Accession:

Select item 1471214.

L-histidine N(alpha)-methyltransferase

This model represents a distinct set of uncharacterized proteins found in the bacteria. Analysis by PSI-BLAST shows remote sequence homology to methyltransferases

Gene:: egtD

GO Terms:

Biological Process:: ergothioneine biosynthetic process (GO:0052699)

Molecular Function:: L-histidine N(alpha)-methyltransferase activity (GO:0052706)

Date:: 2024-10-21

Family Accession:: TIGR03438.1
Method:: HMM

Select item 1234745.

L-histidine N(alpha)-methyltransferase

L-histidine N(alpha)-methyltransferase catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine