Protein Family Models for Protein (Select 520867060) - Protein Family Models

Select item 4274391.

Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster

Domain II of the enzyme dihydroprymidine dehydrogenase binds FAD. Dihydroprymidine dehydrogenase catalyses the first and rate-limiting step of pyrimidine degradation by converting pyrimidines to the corresponding 5,6- dihydro compounds [1]. This domain carries two Fe4-S4 clusters. [1]. 11796730. Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer. Dobritzsch D, Ricagno S, Schneider G, Schnackerz KD, Lindqvist Y;. J Biol Chem. 2002;277:13155-13166. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF026042.5
Method:: HMM

Select item 4240322.

NAD(P)-binding protein

Date:: 2024-08-14

Family Accession:: NF024842.5
Method:: HMM

Select item 4169533.

FAD-dependent oxidoreductase

This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain. [1]. 8805537. Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase. Mande SS, Sarfaty S, Allen MD, Perham RN, Hol WG;. Structure 1996;4:277-286. (from Pfam)

GO Terms:

Molecular Function:: oxidoreductase activity (GO:0016491)

Date:: 2024-10-16

Family Accession:: NF019604.5
Method:: HMM

Select item 4111454.

NAD-binding protein

Date:: 2024-10-16

Family Accession:: NF012299.5
Method:: HMM

Select item 4018005.