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isocitrate lyase/phosphoenolpyruvate mutase family protein
This domain includes the enzyme Phosphoenolpyruvate phosphomutase (EC:5.4.2.9). This protein Swiss:O86937 has been characterised as catalysing the formation of a carbon-phosphorus bond by converting phosphoenolpyruvate (PEP) to phosphonopyruvate (P-Pyr) [1]. This enzyme has a TIM barrel fold. [1]. 9673017. Isolation and characterization of the PEP-phosphomutase and the phosphonopyruvate decarboxylase genes from the phosphinothricin tripeptide producer Streptomyces viridochromogenes Tu494. Schwartz D, Recktenwald J, Pelzer S, Wohlleben W;. FEMS Microbiol Lett. 1998;163:149-157. (from Pfam)
Isocitrate lyase family
isocitrate lyase
isocitrate lyase catalyzes the reversible formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle during growth on fatty acid substrates
Catalyzes the reversible formation of glyoxylate and succinate from isocitrate; glyoxylate bypass pathway
Isocitrate lyase and malate synthase are the enzymes of the glyoxylate shunt, a pathway associated with the TCA cycle.
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