Protein Family Models

This entry represents the C-terminal domain found in transketolase and transketolase-like enzymes [1-5], such as pyruvate dehydrogenase E1 component (OPD1) [4]. Paper describing PDB structure 1ay0. [1]. 9398292. Identification of catalytically important residues in yeast transketolase. Wikner C, Nilsson U, Meshalkina L, Udekwu C, Lindqvist Y, Schneider G;. Biochemistry. 1997;36:15643-15649. Paper describing PDB structure 1gpu. [2]. 11773632. Snapshot of a key intermediate in enzymatic thiamin catalysis: crystal structure of the alpha-carbanion of (alpha,beta-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from Saccharomyces cerevisiae. Fiedler E, Thorell S, Sandalova T, Golbik R, Konig S, Schneider G;. Proc Natl Acad Sci U S A. 2002;99:591-595. Paper describing PDB structure 1itz. [3]. 12913150. Structure and properties of an engineered transketolase from maize. Gerhardt S, Echt S, Busch M, Freigang J, Auerbach G, Bader G, Martin WF, Bacher A, Huber R, Fischer M;. Plant Physiol. 2003;132:1941-1949. Paper describing PDB structure 1l8a. [4]. 11955070. Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution. Arjunan P, Nemeria N, Brunskill A, Chandrasekhar K, Sax M, Yan Y, Jordan F, Guest JR, Furey W;. Biochemistry. 2002;41:5213-5221. Paper describing PDB structure 1r9j. [5]. 15149284. Transketolase from Leishmania mexicana has a dual subcellular localization. Veitch NJ, Maugeri DA, Cazzulo JJ, Lindqvist Y, Barrett MP;. Biochem J. 2004;382:759-767. (from Pfam)

Date:

2024-10-16

The C-terminal domain of transketolase has been proposed as a regulatory molecule binding site [2]. [1]. 8176731. Refined structure of transketolase from Saccharomyces cerevisiae at 2.0 A resolution. Nikkola M, Lindqvist Y, Schneider G;. J Mol Biol 1994;238:387-404. [2]. 1628611. Three-dimensional structure of transketolase, a thiamine diphosphate dependent enzyme, at 2.5 A resolution. Lindqvist Y, Schneider G, Ermler U, Sundstrom M;. EMBO J 1992;11:2373-2379. (from Pfam)

Date:

2024-10-16

This family includes transketolase enzymes, pyruvate dehydrogenases, and branched chain alpha-keto acid decarboxylases. [1]. 8176731. Refined structure of transketolase from Saccharomyces cerevisiae at 2.0 A resolution. Nikkola M, Lindqvist Y, Schneider G;. J Mol Biol 1994;238:387-404. [2]. 1628611. Three-dimensional structure of transketolase, a thiamine diphosphate dependent enzyme, at 2.5 A resolution. Lindqvist Y, Schneider G, Ermler U, Sundstrom M;. EMBO J 1992;11:2373-2379. (from Pfam)

Date:

2024-10-16

transketolase family protein similar to Sinorhizobium fredii Y4mN

Date:

2024-11-19