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Links from Protein

Items: 4

1.

YgjP-like metallopeptidase domain-containing protein

This is a conserved domain containing the catalytic zinc-metallopeptidase (HExxH) catalytic motif. Proteins containing this domain are found in some archaebacteria, as well as Helicobacter pylori. The proteins are 190-240 amino acids long, with the C terminus being the most conserved region, containing three conserved histidines [1,2,3,4]. This domain is found in YgjP from E. coli [4], a predicted metal-dependent hydrolase that hydrolyses UTP to UMP and diphosphate in vitro; and in MJ0123 from Methanocaldococcus jannaschii (also referred to as projannalysin) [3]. [1]. 25802851. MALDI-TOF MS and CD spectral analysis for identification and structure prediction of a purified, novel, organic solvent stable, fibrinolytic metalloprotease from Bacillus cereus B80. Saxena R, Singh R;. Biomed Res Int. 2015;2015:527015. [2]. 26257768. Remote homology and the functions of metagenomic dark matter. Lobb B, Kurtz DA, Moreno-Hagelsieb G, Doxey AC;. Front Genet. 2015;6:234. [3]. 23733187. A novel family of soluble minimal scaffolds provides structural insight into the catalytic domains of integral membrane metallopeptidases. Lopez-Pelegrin M, Cerda-Costa N, Martinez-Jimenez F, Cintas-Pedrola A, Canals A, Peinado JR, Marti-Renom MA, Lopez-Otin C, Arolas JL, Gomis-Ruth FX;. J Biol Chem. 2013;288:21279-21294. [4]. 27941785. Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli. Sevin DC, Fuhrer T, Zamboni N, Sauer U;. Nat Methods. 2017;14:187-194. (from Pfam)

Date:
2024-10-16
Family Accession:
NF013980.5
Method:
HMM
2.
new record, indexing in progress
Family Accession:
3.
new record, indexing in progress
Family Accession:
4.

M48 family metallopeptidase

M48 family metallopeptidase contains the HEXXH zinc-binding motif and may function as an intracellular, membrane-associated zinc metalloprotease

Date:
2024-10-23
Family Accession:
10003681
Method:
Sparcle
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