Protein Family Models

This entry represents the N-terminal domain of the antitoxin component Xre of a type II toxin-antitoxin (TA) system, which is the helix-turn-helix (HTH) DNA binding domain, structurally similar to the Cro repressor, therefore, also referred to as HTH/Cro-like DNA-binding domain [2]. This domain is also found in other antitoxin components, associated with a C-terminal toxin-binding domain Pfam:PF09722 [1,2]. [1]. 30792174. An NAD(+) Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death. Freire DM, Gutierrez C, Garza-Garcia A, Grabowska AD, Sala AJ, Ariyachaokun K, Panikova T, Beckham KSH, Colom A, Pogenberg V, Cianci M, Tuukkanen A, Boudehen YM, Peixoto A, Botella L, Svergun DI, Schnappinger D, Schneider TR, Genevaux P, de Carvalho LPS, Wilmanns M, Parret AHA, Neyrolles O;. Mol Cell. 2019;73:1282-1291. [2]. 30315706. The RES domain toxins of RES-Xre toxin-antitoxin modules induce cell stasis by degrading NAD+. Skjerning RB, Senissar M, Winther KS, Gerdes K, Brodersen DE;. Mol Microbiol. 2019;111:221-236. (from Pfam)

Date:

2024-10-16

This entry represents the C-terminal domain of antitoxin components of a type II toxin-antitoxin (TA) system, including Xre from Pseudomonas putida, MbcA from Mycobacterium sp. and ParS from Sphingobium sp. [1,2,3,4]. This domain interacts with the toxin component and sterically blocks its active site, neutralising its effect [2,3]. These antitoxins also have a HTH domain at the N-terminal. [1]. 30598453. ParST is a widespread toxin-antitoxin module that targets nucleotide metabolism. Piscotta FJ, Jeffrey PD, Link AJ;. Proc Natl Acad Sci U S A. 2019;116:826-834. [2]. 30792174. An NAD(+) Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death. Freire DM, Gutierrez C, Garza-Garcia A, Grabowska AD, Sala AJ, Ariyachaokun K, Panikova T, Beckham KSH, Colom A, Pogenberg V, Cianci M, Tuukkanen A, Boudehen YM, Peixoto A, Botella L, Svergun DI, Schnappinger D, Schneider TR, Genevaux P, de Carvalho LPS, Wilmanns M, Parret AHA, Neyrolles O;. Mol Cell. 2019;73:1282-1291. [3]. 30315706. The RES domain toxins of RES-Xre toxin-antitoxin modules induce cell stasis by degrading NAD+. Skjerning RB, Senissar M, Winther KS, Gerdes K, Brodersen DE;. Mol Microbiol. 2019;111:221-236. [4]. 33384857. Bacterial type II toxin-antitoxin systems acting through post-translational modifications. Zhang SP, Feng HZ, Wang Q, Kempher ML, Quan SW, Tao X, Niu S, Wang Y, Feng HY, He YX;. Comput Struct Biotechnol J. 2020;19:86-93. (from Pfam)

Date:

2024-10-16

DUF2384 domain-containing protein similar to Mycobacterium tuberculosis Rv1990c; DUF2384 domain-containing protein similar to Mycobacterium tuberculosis Rv1990c; helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator with a DUF2384 domain at the C-terminus; MbcA/ParS/Xre antitoxin family protein similar to Sphingobium sp. Prs ADP-ribosylating antitoxin, the antitoxin component of a type II toxin-antitoxin (TA) system, which neutralizes the bacteriostatic effect of cognate toxin ParT by inserting into its active site; XRE (Xenobiotic Response Element) family transcriptional regulator controls the expression of genes involved in stress response; helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator with a DUF2384 domain at the C-terminus; DUF2384 domain-containing protein similar to Mycobacterium tuberculosis Rv1990c; MbcA/ParS/Xre antitoxin family protein similar to Sphingobium sp. Prs ADP-ribosylating antitoxin, the antitoxin component of a type II toxin-antitoxin (TA) system, which neutralizes the bacteriostatic effect of cognate toxin ParT by inserting into its active site; MbcA/ParS/Xre antitoxin family protein similar to Sphingobium sp. Prs ADP-ribosylating antitoxin, the antitoxin component of a type II toxin-antitoxin (TA) system, which neutralizes the bacteriostatic effect of cognate toxin ParT by inserting into its active site; Y4oB family protein is a DUF2384 domain-containing protein; similar to Sinorhizobium fredii protein Y4oB

Date:

2017-12-21

Proteins in this family are found almost exclusively in the Proteobacteria, but also in Gloeobacter violaceus PCC 7421, a cyanobacterium. This family was proposed by Makarova, et al. (2009) to be the antitoxin component of a new class of type 2 toxin-antitoxin system, or addiction module.

Date:

2021-04-27